But call 911 if your symptoms feel life threatening or if you think youre having a medical emergency. Then your body uses that iron to make hemoglobin and RBCs. endobj Do not double the dose to catch up. Venofer (iron sucrose) is given as an injection into the veins (intravenously or IV) by a trained healthcare provider. It belongs to a class of medications known as iron replacement products. Theseside effectsmay last as long as they are undercancer treatment. And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. They can tell you about other medications that may work well for you. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Best food forward: Are algae the future of sustainable nutrition? Other side effects include: Common (may affect up to 1 in 10 users) Temporary taste changes (especially metallic taste) Low blood pressure or high blood pressure. With a delayed reaction, your body reacts to a drug that youve been exposed to in the past without having a reaction. In this group, after 35 days of treatment: In clinical studies, Injectafer was effective in treating IDA in adults with CKD who didnt require dialysis. No, Injectafer itself wont make you gain weight. For some people, it may be OK to continue taking a multivitamin that contains iron. Usually, but not always, the bigger a person is the slower it takes for drugs to break down and leave the body. Injectafer comes as a liquid solution inside vials. What to know about iron deficiency anemia, took oral iron treatment and didnt have improvement in their IDA or had side effects that couldnt be managed, or, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, have a medical condition that affects their bodys ability to absorb phosphorus, take medications that affect how well their, ferrous sulfate (Fer-Iron, Slow-FE, Feosol), people who took Injectafer had their hemoglobin level increase by an average of 1.1 grams per deciliter (g/dL), people who took Venofer had their hemoglobin increase by an average of 0.9 g/dL. . * This is a partial list of mild side effects from Injectafer. This may be helped by giving the medication more slowly or at a lower dose. You may report side effects to FDA at 1-800-FDA-1088. If you have questions about side effects, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. If you have questions about using Injectafer for anemia during pregnancy, talk with your doctor. Injectafer isnt a medication that youll take regularly on a schedule. Drug class: Iron products. Last updated on Feb 20, 2023. The actual price youll pay depends on your insurance plan and any copays, your location, and the pharmacy you use. fever, cold or flu symptoms (sore throat, cough, stuffy nose, sneezing); bruising or irritation where the medicine was injected. Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in adult and pediatric (2 years of age and older) patients with chronic kidney disease (CKD), and is administered only by or under the supervision of your healthcare provider. We comply with the HONcode standard for trustworthy health information. Allergic reactions are most likely to occur within 30 minutes of receiving Venofer. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Venofer is for use in adults and children at least 2 years old. An iron infusion is a way to increase the body's iron levels quickly. Hemoglobin is a protein thats found inside your red blood cells. Blood tests may be needed to check for unwanted effects. He said sometimes the reaction does show up after a few doses and unfortunately it takes longer to get over it. Get emergency medical help if you have signs of an allergic reaction to Venofer: hives, rash, itching; feeling light-headed; difficulty breathing; swelling of your face, lips, tongue, or throat. Hypophosphatemia seems to mostly occur in people who are already at risk for low phosphorus levels. Canada residents can call a provincial poison control center. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Injectafer is available only as a brand-name medication. I got Venofer twice in the last few years and now my iron deficiency is worse than ever, first time my hemoglobin is down to 11,2. Phosphorus is an electrolyte that your body needs in order to make energy. You may need extra iron because of blood loss during kidney dialysis. There isnt a known interaction between Injectafer and alcohol. Both of theseside effectscould worsen depression and lead tolife-threateningconsequences. However, side effects at the 150 mg dose may indicate that you might not . Terminal half-life ranges from 7 to 12 hours. Below are examples of these side effects. It is important to get each dose of this medication as scheduled. Common side effects of Venofer include: muscle cramps, nausea, vomiting, stomach pain, strange taste in the mouth or decreased sense of taste, diarrhea, constipation, headache, cough, sore throat, sinus pain, congestion, back pain, joint pain, dizziness, weakness, tired feeling, anxiety, ear pain, swelling of the arms/legs, or With anemia, you have a low level of red blood cells (RBCs) in your body. Instead, youll start by receiving just one treatment course of Injectafer. Your doctor will go over your Patients with celiac disease (gluten intolerance). You should always consult your doctor or another healthcare professional before taking any medication. Youll receive doses of Injectafer from a healthcare professional at a medical facility. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Injectafer isnt known to interact with any other medications, herbs, supplements, or foods. Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. Follow your doctor's directions carefully. Some products that may interact with this drug include: vitamin products, other iron-containing products. Find out what health conditions may be a health risk when taken with Venofer Vial You may report side effects to the FDA at 1-800-332-1088. wAd**CgI%"nn{Oa[q{r5 Keep all drugs in a safe place. This material is provided for educational purposes only and is not intended for medical advice, diagnosis, or treatment. Venofer may cause serious side effects including: problems with your dialysis vein access point, chest pain, severe headache, blurred vision, pounding in your neck or ears, lightheadedness, pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, and fever Get medical help right away, if you have any of the symptoms listed above. Its caused by your body not having enough iron, which is needed to make hemoglobin. So theres no recommended pediatric dosage for Injectafer. The dosing for iron replacement treatment in pediatric patients less than 2 years old with Peritoneal or Hemodialysis-Dependent CKD or Non-Dialysis-Dependent CKD have not been established. (Hemoglobin is a protein thats found inside your red blood cells.). 4 0 obj Source: Wolters Kluwer Health. Depending on your doctors instructions and Theyll do this by checking certain blood tests. Storage Condition Store in a cool and dry place protected from light. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. For instance, those who are taking other medications or supplements as part of home remedies may continue to suffer from the ill effects of their new medication because they dontinteract. Pain, swelling, or redness at the injection site may occur. Pain, swelling, or redness at the injection site may occur. Some drugs may have another patient information leaflet. Learn about the causes, symptoms, diagnosis, and treatment of this. "The most common side effects to COVID vaccines include pain at the injection site, fevers, chills, nausea, headaches, tiredness, and painful or swollen lymph nodes in the arm where the vaccine. The use of Injectafer and Feraheme in treating IDA in these adults has been directly compared in a clinical study. Cardiovascular health: Insomnia linked to greater risk of heart attack. Side effects: DayQuil can cause side effects such as drowsiness, dizziness, nausea, vomiting, and stomach upset. Following an LSD trip, users may experience a sort of 'comedown.'. Those going through thismedical conditionshould speak to theircare teamfor support andguidance. This is why the FDA hasa programcalledMedWatchthat encourages Americans to report adversereactions. How is Venofer (iron sucrose) given? This website is intended for use by US patients. These side effects can range from being mild to severe. People who weigh 110 pounds (about 50 kilograms) or more will receive two separate Injectafer doses of 750 milligrams each. However, diarrhea it isnt very common in people using Injectafer. A variety of tests can diagnose iron deficiency anemia. The infusion will take between 15-30 minutes if it is given in. Other drugs are available that can treat iron deficiency anemia (IDA). One class of immune checkpoint inhibitors targets the protein PD-1, which acts as a brake to keep the immune system in check. Drug interactions: DayQuil can interact with other medications, including prescription drugs, over-the-counter medications, and herbal supplements. Your doctor will recommend whether you should stop taking your multivitamin or any other supplements. Use of the term female in this article refers to sex assigned at birth. Note: The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. If you have questions about the blood tests youll need to have done to monitor your anemia, talk with your doctor. This can be very helpful in . Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. Here we look at how Injectafer and Feraheme are alike and different. If you would like to report to the FDA a side effect youve had with Injectafer, you can do so through MedWatch. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. You may report side effects to the FDA at 1-800-332-1088. Its given by either intravenous (IV) infusion or slow IV injection. Talk with your doctor. Have blood work checked as you have been told by the doctor. The insurance company will review the prior authorization request and decide if the drug will be covered. Innovators Monograph chills difficulty with moving ear congestion or pain flushed, dry skin fruit-like breath odor increased hunger or thirst increased urination lack or loss of strength pain or redness at the injection site pale skin at the injection site runny nose, sneezing sore throat unexplained weight loss Rare Burning, dry, or itching eyes Ask your doctor or healthcare provider if Venofer is the right choice for you. Call your doctor for instructions if you miss an appointment for your Venofer injection. This includes your doctors, nurses, pharmacists, and dentists. We cancelled my 5th because of the reaction. Their medical staff can help you set up another time to receive your Injectafer dose. Call your doctor for medical advice about side effects. Its important to note that youll get Injectafer doses from a doctor or healthcare professional in a medical facility. Medically reviewed by Sanjai Sinha, MD. These lists contain up to 10 of the most common mild side effects that can occur with Injectafer, with Venofer, or with both drugs (when taken individually). Call your doctor for medical advice about side effects. But even if youre not at risk for the condition, your doctor may still monitor your phosphorus levels. Here we look at how Injectafer and Venofer are alike and different. However, some people can experienceside effectsfor much longer - days, months, or indefinitely. Depending on your anemia symptoms, your weight changes may be different than those described here. The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need. Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: Injectafer is indicated to treat iron deficiency anemia (IDA) in adults who meet one of the following criteria: Injectafer is administered intravenously, either by intravenous (IV) infusion or as an undiluted, slow IV push. Since someallergic reactionscan belife-threatening, its essential to discuss any adverse events previously experienced with the prescribingphysician. Your body then uses the iron from Injectafer to make hemoglobin and new RBCs. HRT, like other medications, does have some side effects and these are thought to be quite common. Without enough hemoglobin, the right amount of oxygen may not reach certain parts of your body. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. In clinical studies, people who took Injectafer had their hemoglobin level improve as early as 35 days after receiving treatment. For this purpose, Injectafer is approved for use in adults who either: Venofer is also approved to treat IDA. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. Keep all regular medical and laboratory appointments. Tell your caregivers right away if you have: problems with your dialysis vein access point; high blood pressure - severe headache, blurred vision, pounding in your neck or ears; low blood pressure - a light-headed feeling, like you might pass out; or. These nutrients include iron, vitamin B12, and folate. All rights reserved. This is not a complete list of side effects and others may occur. Now I've just got mild nausea and have felt faint/dizzy a few times which is rare for me. Once you have waited for 30 minutes after the injection, you may go home, providing you are feeling well. Its because everyones body is different. (One treatment course includes two doses of the drug.) Once inside your body, ferric carboxymaltose releases iron into your system. I can't take oral supplements because they cause horrible debilitating Constipation. In clinical trials, pregnant females* who took Injectafer didnt have any negative outcomes, such as premature delivery or pregnancy loss. fever. ByDr. While this may seem like it would be out of a persons body quickly, the rate of it being broken down is much slower afterward. In the second group, some people switched from taking iron by mouth to taking Injectafer. These pregnancy-related problems include preterm delivery and low birth weight of your infant. If you do breastfeed while youre taking Injectafer, the drugs manufacturer recommends that you monitor your child for side effects of the drug. Which tests can diagnose iron deficiency anemia? An example of a drug interaction that many people are not aware of isgrapefruitjuice and statins. Infusions should be administered over at least 15 minutes. For example, if someone takes 100 mg of a drug, only half of it will be in the bloodstream in a couple ofhours. WebMD does not provide medical advice, diagnosis or treatment. 5 0 obj Serious side effects, which are explained in more detail below in Side effect details, include: You may wonder how often certain side effects occur with this drug. If you need financial support to pay for Injectafer, or if you need help understanding your insurance coverage, help is available. The drug helps increase your hemoglobin level back to a value thats within the normal range. Headache. 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. And babies born to those who took Injectafer during pregnancy didnt have any major congenital anomalies (also sometimes called birth defects). (A generic drug is an exact copy of the active drug in a brand-name medication.). No, you most likely wont take Injectafer long term. Before you receive Venofer, tell your doctor if you have low blood pressure, hepatitis, or if you have received many blood transfusions in the past. You will be watched closely by your doctor for 30 minutes after each dose. Its not known for sure how often this condition occurred during clinical trials, or if it occurred at all during the trials. People who are ongoingcancer treatmentwithradiation therapyor takingchemotherapy drugsmay be more susceptible toside effects. Venofer (iron sucrose) can also be mixed in a saline solution and given through an IV over a longer time. endobj For instance, there are some experts who believe there are long-lastingside effectsfromCOVIDthat were not aware of just yet. One study of just under 5000 HRT users found that 43% were affected. After getting one treatment course of Injectafer, you typically wont need another dose of the drug again unless your anemia comes back. Review our medical disclaimer. Consult the product instructions and your pharmacist for storage details. <> 2023 Medicine.com All rights reserved. Heres some detail on certain side effects this drug may cause. Its FDA-approved to treat iron deficiency anemia (IDA) in adults. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Yes, in some cases it may. Other drugs may interact with iron sucrose, including prescription and over-the-counter medicines, vitamins, and herbal products. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. I had my first infusion of 1gm 10 days ago. Iron is an essential nutrient needed to maintain energy levels and keep you healthy. . Talk with the doctor. If either is present, do not use the liquid. Serious side effects should be reported to a physician and/or PharmD for medical advice. Symptoms of a severe allergic reaction can include: Because of the risk of allergic reaction with Injectafer, your healthcare professional will monitor you for at least 30 minutes after you get each dose of the drug. With IDA, you have low hemoglobin levels. People from different ethnic backgrounds process medications differently. With IV infusion, the drug is given as a slow drip into your vein over a period of time. Learn more about these, as well as the symptoms, diagnosis, and treatments. Tell your doctor if you are pregnant or plan to become pregnant. Common MRI side effects include dizziness, anxiety, headache, nausea, hearing loud noises, and feeling chilled or hot in the MRI scanner. Read all information given to you. Tell all of your health care providers that you take Venofer. Venofer is used to treat iron deficiency anemia in people with kidney disease. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. In one study, treatment with Injectafer was compared with that of iron thats taken by mouth. The following information describes dosages that are commonly used or recommended. Theseeffects of medicine on thebodycan also lead to medication non-compliance and worsening of themedical conditionthey are meant to treat. Many patients with kidney disease cannot get enough iron from food and require injections. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Venofer only for the indication prescribed. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. What should I know regarding pregnancy, nursing and administering Venofer Vial to children or the elderly. This product may contain inactive ingredients, which can cause allergic reactions or other problems. During pregnancy, this medication should be used only when clearly needed. These lists dont include all possible side effects. Learn how to store and discard medical supplies safely. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. And this person had gotten their first dose of the drug without having an allergic reaction. If youre taking iron pills, be sure to tell your doctor before starting Injectafer. For some people, after receiving one treatment course (two doses) of Injectafer, their IDA is resolved. But for other people, their IDA returns after treatment with Injectafer. For additional information, contact your healthcare provider. For more information about taking Injectafer during pregnancy, see the section Injectafer and pregnancy above. All of the people took iron by mouth for 2 weeks. For people weighing less than 50 kg, administer Injectafer in two doses of 15 mg/kg of body weight, at least 7 days apart. This gives a total cumulative dose of 1,500 mg of Injectafer. To make sure Venofer injection is safe for you, tell your doctor if you have: hemochromatosis or iron overload (the buildup of excess iron). The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. These changes could help improve your anemia on a long-term basis. The following lists contain some of the key side effects that may occur while taking Injectafer. But so far I feel better than before the infusion. Venofer® (iron sucrose injection, USP) is available by prescription only. Brand-name medications usually cost more than generics. After 5 weeks of treatment: This study didnt determine if either drug was better than the other. But its only approved for use in people with CKD who may or may not need dialysis. Throw away unused or expired drugs. You may also need to monitor your blood pressure at home. * Sex and gender exist on spectrums. *Patients are calculated based on an estimated annual cumulative dose. Potential injection site discoloration has happened. There may be drug take-back programs in your area. Last reviewed . They have been a god send. Call your doctor for medical advice about side effects. Available for Android and iOS devices. All patients receiving Venofer require periodic blood tests to monitor the amount of iron in the blood. Be ready to tell or show what was taken, how much, and when it happened. Examples of other drugs that may be used to treat IDA include: Your doctor will recommend the drug thats right for you depending on the severity of your anemia and any other medical conditions you may have. But the length of time that this may take varies from person to person. Notify your healthcare provider if you are pregnant, or planning to get pregnant or breastfeeding. So we cant say for sure whether the drug is safe to use while youre pregnant. Venofer is given as an infusion into a vein. He is an Affiliate Specialist of the American College of Medical Genetics and Genomics(ACMG), an Associate of the American College of Preventive Medicine(ACPM), and a member of the National Society of Genetic Counselors(NSGC). This hormone is made by your kidneys. The drug helps increase your hemoglobin level back to a value thats within the normal range. chest pain. (A class of medications describes a group of drugs that work in the same way.). No, you wont need to take iron pills while youre using Injectafer. This website is intended for use by US healthcare professionals only. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. While the side effects that occur during treatment with these drugs are increasingly well-cataloged, the long-term side effects that may result from receiving these drugs are only beginning to be studied. Injectafer contains the active drug ferric carboxymaltose. With slow IV injection, the drug is given as a single, slow injection into your vein. If administering via IV infusion, up to 750 mg of Injectafer should be diluted in no more than 250 mL of sterile 0.9% sodium chloride solution (NaCl). The actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use. A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. So the goal of IDA treatment with Injectafer is to bring your hemoglobin level back to a value thats within normal range. Common Venofer side effects may include: fever, cold or flu symptoms ( sore throat, cough, stuffy nose, sneezing); high or low blood pressure; headache, dizziness; nausea, vomiting, diarrhea; muscle or joint pain, back pain; pain or swelling in an arm or leg; itching; or bruising or irritation where the medicine was injected. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. If youre wondering how longside effectslast, youll be happy to know they can last just a few hours. Venofer (iron sucrose injection, USP) Rx Only DESCRIPTION Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. The researchers found that compared with their hemoglobin level before the study: But the actual price youll pay for either drug depends on your insurance plan, your location, and the pharmacy you use.
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